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A buffer is a magical device who will prevent your cables to ruin your magnificent tone.Things happens in life.
Like this strange phenomenon that makes your guitar tone different between when you plug your instrument with a 1 meter cable straight into your amp and when you run 5 meters of cables through a ton of pedals . Strangely you sound smoother in the second case... Thus you buy lots of new high quality cables to try to avoid this... It's a good idea, likely to be deceiving.
With a great length of cables, even with very good quality ones, you'd better get a buffer, like the bluffer.
It should be placed at the end of the cable running out of your instrument. UNLESS a fuzz, like the fuzz factory is present in your pedals: put the buffer just after. (You can also put it before, but your fuzz will never be the same...)